Publication:
Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents

Issued Date

2005-05-01

Resource Type

Article

ISSN

00221899

DOI

10.1086/428450

Other identifier(s)

2-s2.0-20244369447

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Infectious Diseases. Vol.191, No.9 (2005), 1427-1434

Suggested Citation

Paul M. Coplan, Swati B. Gupta, Sheri A. Dubey, Punnee Pitisuttithum, Alex Nikas, Bernard Mbewe, Efthyia Vardas, Mauro Schechter, Esper G. Kallas, Dan C. Freed, Tong Ming Fu, Christopher T. Mast, Pilaipan Puthavathana, James Kublin, Kelly Brown Collins, John Chisi, Richard Pendame, Scott J. Thaler, Glenda Gray, James Mcintyre, Walter L. Straus, Jon H. Condra, Devan V. Mehrotra, Harry A. Guess, Emilio A. Emini, John W. Shiver Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents. Journal of Infectious Diseases. Vol.191, No.9 (2005), 1427-1434. doi:10.1086/428450 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17005

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Title

Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents

Author(s)

Paul M. Coplan
 Swati B. Gupta
 Sheri A. Dubey
 Punnee Pitisuttithum
 Alex Nikas
 Bernard Mbewe
 Efthyia Vardas
 Mauro Schechter
 Esper G. Kallas
 Dan C. Freed
 Tong Ming Fu
 Christopher T. Mast
 Pilaipan Puthavathana
 James Kublin
 Kelly Brown Collins
 John Chisi
 Richard Pendame
 Scott J. Thaler
 Glenda Gray
 James Mcintyre
 Walter L. Straus
 Jon H. Condra
 Devan V. Mehrotra
 Harry A. Guess
 Emilio A. Emini
 John W. Shiver

Other Contributor(s)

Merck Research Laboratories
 Mahidol University
 Malawi College of Medicine
 Ministry of Population and Health
 Universidade Federal do Rio de Janeiro
 Universidade Federal de Sao Paulo
 University of Witwatersrand
 Intl. Partnership for Microbicides
 The University of North Carolina at Chapel Hill
 International AIDS Vaccine Initiative
 International Partnership for Microbicides

Abstract

Background. The genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades. Methods. Cellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-γ enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the United States. Cross-clade reactivity was evaluated by use of the ratio of responses to heterologous versus homologous (infecting) clades of HIV-1. Results. Cellular immune responses were predominantly focused on viral Gag and Nef proteins. Cross-clade reactivity of cellular immune responses to HIV-1 clade A, B, and C proteins was substantial for Nef proteins (ratio, 0.97 [95% confidence interval, 0.89-1.05]) and lower for Gag proteins (ratio, 0.67 [95% confidence interval, 0.62-0.73]). The difference in cross-clade reactivity to Nef and Gag proteins was significant (P < .0001). Conclusions. Cross-clade reactivity of cellular immune responses can be substantial but varies by viral protein. © 2005 by the Infectious Diseases Society of America. All rights reserved.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/17005

Collections

Scopus 2001-2005