Publication: Corneal abnormalities in diabetes
Issued Date
2001-08-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0035431965
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.84, No.8 (2001), 1075-1083
Suggested Citation
Janpen Siribunkum, Panida Kosrirukvongs, Apichart Singalavanija Corneal abnormalities in diabetes. Journal of the Medical Association of Thailand. Vol.84, No.8 (2001), 1075-1083. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26739
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Corneal abnormalities in diabetes
Other Contributor(s)
Abstract
Objective : To compare corneal thickness and endothelial morphology in patients with diabetes mellitus and age-matched normal subjects, and to determine whether the duration of diabetes mellitus, severity of diabetic retinopathy, and glycemic control are correlated with these measurements. Design : Single center, case-control study. Participants : Sixty eyes of thirty diabetic patients and sixty eyes of thirty healthy non-diabetic subjects were studied. Intervention : Corneal thickness was measured by ultrasonic pachymeter. Corneal endothelial morphology was examined with a contact specular microscope. Main Outcome Measures : Corneal endothelial cell density, mean cell area, coefficient of variation, percentages of hexagonal cells, and corneal thickness were measured. Results : There was statistically significant increased corneal endothelial cell density and decreased mean endothelial cell area in the diabetic patients. The diabetic corneas had an increased coefficient of variation of endothelial cell area, a decreased percentage of hexagonal endothelial cell and an increased corneal thickness compared with the control subjects, but these differences were not statistically significant. The duration of diabetes mellitus was significantly correlated with pleomorphism, polymegathism and corneal thickness. Severity of diabetic retinopathy was correlated with endothelial cell density, but these correlations were low. The corneal changes were not correlated with glycemic control. Conclusions : The diabetic corneas tended to be thicker and had more pleomorphism and polymegathism, though this was not statistically significant. Duration of diabetes mellitus correlated significantly with these corneal changes. This suggests that corneal changes should be evaluated and confirmed before intraocular surgery in chronic diabetic patients.