Publication: Cervical Cancer Markers: Epigenetics and microRNAs
Issued Date
2018-03-21
Resource Type
ISSN
19437730
00075027
00075027
Other identifier(s)
2-s2.0-85044644402
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Lab Medicine. Vol.49, No.2 (2018), 97-111
Suggested Citation
Vishuda Laengsri, Usanee Kerdpin, Chotiros Plabplueng, Lertyot Treeratanapiboon, Pornlada Nuchnoi Cervical Cancer Markers: Epigenetics and microRNAs. Lab Medicine. Vol.49, No.2 (2018), 97-111. doi:10.1093/labmed/lmx080 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45207
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Cervical Cancer Markers: Epigenetics and microRNAs
Other Contributor(s)
Abstract
© American Society for Clinical Pathology 2018. All rights reserved. Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary. This review focuses on the role of epigenetic changes, particularly microRNAs (miRNAs), to CC. Several miRNAs that associated with CC potentially have the advantage of being early biomarkers. Moreover, altered serum miRNAs or single nucleotide polymorphisms in miRNA patterns may predict disease progression.