Publication:
Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study

Issued Date

2020-11-05

Resource Type

Article

ISSN

15376591

DOI

10.1093/cid/ciz1143

Other identifier(s)

2-s2.0-85095861725

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Vol.71, No.8 (2020), e270-e280

Suggested Citation

Nittaya Phanuphak, Sirinya Teeraananchai, Rawiwan Hansudewechakul, Sivaporn Gatechompol, Kulkanya Chokephaibulkit, Hanh Le Dung Dang, Dan Ngoc Hanh Tran, Jullapong Achalapong, Nipat Teeratakulpisarn, Amphan Chalermchockcharoenkit, Manopchai Thamkhantho, Tippawan Pankam, Thida Singtoroj, Wichai Termrungruanglert, Surasith Chaithongwongwatthana, Stephen J. Kerr, Annette H. Sohn Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Vol.71, No.8 (2020), e270-e280. doi:10.1093/cid/ciz1143 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60030

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Title

Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study

Author(s)

Nittaya Phanuphak
 Sirinya Teeraananchai
 Rawiwan Hansudewechakul
 Sivaporn Gatechompol
 Kulkanya Chokephaibulkit
 Hanh Le Dung Dang
 Dan Ngoc Hanh Tran
 Jullapong Achalapong
 Nipat Teeratakulpisarn
 Amphan Chalermchockcharoenkit
 Manopchai Thamkhantho
 Tippawan Pankam
 Thida Singtoroj
 Wichai Termrungruanglert
 Surasith Chaithongwongwatthana
 Stephen J. Kerr
 Annette H. Sohn

Other Contributor(s)

Thai Red Cross Agency
 Chulalongkorn University
 Kirby Institute
 Kasetsart University
 The HIV Netherlands Australia Thailand Research Collaboration
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Children's Hospital 1
 TREAT Asia/amfAR-The Foundation for AIDS Research
 Chiangrai Prachanukroh Hospital
 Hung Vuong Hospital

Abstract

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uninfected youth for persistent anogenital human papillomavirus (HPV) infection, due to prolonged immunodeficiency. METHODS: A 3-year cohort study was conducted between 2013 and 2017 among Thai and Vietnamese PHIV and HIV-uninfected females 12-24 years, matched by age group and number of lifetime sexual partners. For HPV genotyping, cervical and anal samples were obtained at baseline and annually. Vaginal samples were collected at baseline and every 6 months. Factors associated with high-risk HPV (HR-HPV) persistence and incidence were assessed. RESULTS: We enrolled 93 PHIV and 99 HIV-uninfected females. Median age was 19 (interquartile range [IQR] 18-20) years. For the 7 HR-HPV types (16, 18, 31, 33, 45, 52, 58) in the nonavalent HPV vaccine, PHIV had significantly higher incidence (P = .03) and persistence (P = .01) than HIV-uninfected youth over a 3-year period. Having HIV (adjusted hazard ratio [aHR] 2.1, 95% confidence interval [CI] 1.1-3.9) and ever using illegal substances (aHR 4.8, 95% CI 1.8-13.0) were associated with incident 7 HR-HPV infections. HIV-positive status (adjusted prevalence ratio [aPR] 2.2, 95% CI 1.5-3.2), recent alcohol use (aPR 1.75, 95% CI 1.2-2.5), and higher number of lifetime partners (aPR 2.0, 95% CI 1.4-3.1, for 3-5 partners; aPR 1.93, 95% CI 1.2-3.2, for ≥6 partners) were significantly associated with persistent 7 HR-HPV infections. CONCLUSIONS: Female PHIV were at higher risk of having anogenital HR-HPV acquisition and persistence. Primary and secondary prevention programs for HPV infection and HPV-related diseases should be prioritized for PHIV children and youth.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/60030

Collections

Scopus 2020