Publication: Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia
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Issued Date
2021-03-01
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ISSN
22146237
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2-s2.0-85104080288
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical and Translational Endocrinology. Vol.24, (2021)
Suggested Citation
Hataikarn Nimitphong, Sunee Saetung, La or Chailurkit, Suwannee Chanprasertyothin, Boonsong Ongphiphadhanakul Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia. Journal of Clinical and Translational Endocrinology. Vol.24, (2021). doi:10.1016/j.jcte.2021.100255 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76255
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Title
Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia
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Abstract
Aims: Vitamin D deficiency is associated with a number of noncommunicable conditions. We conducted a randomised controlled trial to determine the effect of vitamin D supplementation on serum uric acid concentration in patients with prediabetes, in whom hyperuricaemia is common. Methods: Seventy-one volunteers (35–80 years), with impaired fasting glucose and/or impaired glucose tolerance were randomised to three groups, vitamin D3, vitamin D2 and control, and followed for 12 months. Results: After 12 weeks, vitamin D supplementation was associated with a reduction in serum uric acid concentration in participants with baseline uric acid concentration > 6 mg/dL, but no significant change was observed in controls. We then assessed the dose–response relationship between vitamin D supplementation and the change in serum uric acid concentration and found that the change in serum total 25-hydroxyvitamin D did not correlate with the change in serum uric acid that occurred during vitamin D supplementation. The factors associated with larger reductions in serum uric acid were a higher baseline serum uric acid and a larger increase in serum 1,25-dihydroxyvitamin D. Conclusions: Vitamin D supplementation lowers serum uric acid in prediabetic patients with hyperuricaemia, and supplementation might be considered to help alleviate hyperuricaemia in these patients.