Publication: A glance of the blood stage transcriptome of a Southeast Asian Plasmodium ovale isolate
Issued Date
2019-01-01
Resource Type
ISSN
19352735
19352727
19352727
Other identifier(s)
2-s2.0-85075814649
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS Neglected Tropical Diseases. Vol.13, No.11 (2019)
Suggested Citation
Awtum M. Brashear, Wanlapa Roobsoong, Faiza A. Siddiqui, Wang Nguitragool, Jetsumon Sattabongkot, Margarita M. López-Uribe, Jun Miao, Liwang Cui A glance of the blood stage transcriptome of a Southeast Asian Plasmodium ovale isolate. PLoS Neglected Tropical Diseases. Vol.13, No.11 (2019). doi:10.1371/journal.pntd.0007850 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52217
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A glance of the blood stage transcriptome of a Southeast Asian Plasmodium ovale isolate
Other Contributor(s)
Abstract
© 2019 Brashear et al. Plasmodium ovale accounts for a disproportionate number of travel-related malaria cases. This parasite is understudied since there is a reliance on clinical samples. We collected a P. ovale curtisi parasite isolate from a clinical case in western Thailand and performed RNAseq analysis on the blood stage transcriptomes. Using both de novo assembly and alignment- based methods, we detected the transcripts for 6628 out of 7280 annotated genes. For those lacking evidence of expression, the vast majority belonged to the PIR and STP1 gene families. We identified new splicing patterns for over 2500 genes, and mapped at least one untranslated region for over half of all annotated genes. Our analysis also detected a notable presence of anti-sense transcripts for over 10% of P. ovale curtisi genes. This transcriptomic analysis provides new insights into the blood-stage biology of this neglected parasite.