Publication:
Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents

Issued Date

2006-01-16

Resource Type

Article

ISSN

00404039

DOI

10.1016/j.tetlet.2005.11.016

Other identifier(s)

2-s2.0-28844486620

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron Letters. Vol.47, No.3 (2006), 345-348

Suggested Citation

Patcharaporn Sae-Lao, Prasat Kittakoop, Shuleewan Rajviroongit Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents. Tetrahedron Letters. Vol.47, No.3 (2006), 345-348. doi:10.1016/j.tetlet.2005.11.016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23097

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Title

Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents

Author(s)

Patcharaporn Sae-Lao
 Prasat Kittakoop
 Shuleewan Rajviroongit

Other Contributor(s)

Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

The total synthesis of antimalarial and cyclooxygenase inhibitors, racemosol and de-O-methylracemosol, is described. The key steps involved the lateral lithiation reaction of ortho-methyl tolulate and the pyran formation via a tandem demethylation-cyclization reaction. © 2005 Elsevier Ltd. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/23097

Collections

Scopus 2006-2010