Publication: Induced autophagy reduces virus output in dengue infected monocytic cells
Issued Date
2011-09-15
Resource Type
ISSN
10960341
00426822
00426822
Other identifier(s)
2-s2.0-80052022521
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Virology. Vol.418, No.1 (2011), 74-84
Suggested Citation
Mingkwan Panyasrivanit, Michael P. Greenwood, David Murphy, Ciro Isidoro, Prasert Auewarakul, Duncan R. Smith Induced autophagy reduces virus output in dengue infected monocytic cells. Virology. Vol.418, No.1 (2011), 74-84. doi:10.1016/j.virol.2011.07.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11995
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Title
Induced autophagy reduces virus output in dengue infected monocytic cells
Abstract
While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susceptible to antibody enhanced infection. This study sought to determine the involvement of autophagy in the DENV infection of monocytic cells, using U937 cells as a model system. While the induction of autophagy was seen in response to DENV-2 infection, biochemical induction of autophagy resulted in a significant decrease in virus output. Down regulation of autophagy resulted in only a very slight increase in intracellular virus levels. In monocytic cells autophagy is not a significant part of the DENV replication mechanism, and there are distinct cell type specific differences in the DENV-autophagy interaction. © 2011 Elsevier Inc.