Publication: Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius
Issued Date
2006-01-01
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ISSN
00320943
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2-s2.0-32644435414
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.72, No.1 (2006), 60-62
Suggested Citation
Patoomratana Tuchinda, Anawat Kumkao, Manat Pohmakotr, Samaisukh Sophasan, Thawatchai Santisuk, Vichai Reutrakul Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius. Planta Medica. Vol.72, No.1 (2006), 60-62. doi:10.1055/s-2005-873141 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23113
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Title
Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius
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Abstract
The arylnaphthalide lignan glycosides, taxodiifoloside (1), cleistanthoside A (2), cleistanthin A (3) and cleistanthin A methyl ether (4), together with a triterpene, glochidone (5), have been isolated from the aerial parts of Phyllanthus taxodiifolius. The structures were established using spectral and chemical methods. Compounds 3 and 4, as well as the derivatives 2a and 3a exhibited potent cytotoxic activities with GI50values in the range of 10-7-10-9M in five cultured mammalian cancer cell lines while the new compound 1 showed moderate activity (GI50in the order of 10-6M). Compounds 2 and 5 were inactive in all tested cell lines. © Georg Thieme Verlag KG Stuttgart.