Publication: HLA-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)
Issued Date
2006-03-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-33746060466
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.2 (2006), 357-365
Suggested Citation
Pensiri Himmunngan, Somkiat Sangwatanaroj, Songsak Petmitr, Duangkamol Viroonudomphol, Pakorn Siriyong, Pimpicha Patmasiriwat HLA-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families). Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.2 (2006), 357-365. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23805
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Title
HLA-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)
Abstract
Thai Sudden Unexplained Death Syndrome (Thai SUDS), or Lai-Tai, is a major health problem among rural residents of northeastern Thailand. The cause has been identified as a genetic disease. SUDS, a disorder found in Southeast Asia, is characterized by an abnormal electrocardiogram with ST-segment elevation in leads V1-V3, identical to that seen in Brugada Syndrome (Brugada Sign, BS) and sudden death due to ventricular fibrillation and cardiac arrest (represents an arrhythmogenic marker that identifies high-risk for SUDS). SUDS victims have a sleeping disorder (narcolepsy). The HLA-DR locus is tightly associated with narcoleptic Japanese patients and HLA-DR2, DQ haplotypes were also found in Oriental narcoleptic patients. These circumstances prompted us to study the association between the disease and HLA Class II by HLA DNA typing using a PCR-SSO method, with five Thai SUDS families (18 BS-positive subjects as the cases, and 27 BS-negatives as the controls). We found that the HLA-DRB1*12021 allele was significantly increased in BS-positive subjects (p=0.02; OR=4.5), the same as the HLA-DRB1* 12021-DQB1*0301/09 haplotype (p=0.01; OR=7.95). Our data suggests that the HLA-DRB1* 12021 allele associated with BS and the HLA-DRB1*12021-DQB1*0301/09 is a haplotype susceptible to arrhythmogenic markers that can identify a high risk for SUDS.