Publication: Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
Issued Date
2006-04-01
Resource Type
ISSN
10991573
0951418X
0951418X
DOI
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2-s2.0-33645899625
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.20, No.4 (2006), 307-309
Suggested Citation
C. Ichino, N. Soonthornchareonnon, W. Chuakul, H. Kiyohara, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, S. Omura, Haruki Yamada Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity. Phytotherapy Research. Vol.20, No.4 (2006), 307-309. doi:10.1002/ptr.1850 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23172
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Title
Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity
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Abstract
To discover antimalarial substances from plants cultivated in Thailand 80%-EtOH extracts from selected plants were screened for in vitro antimalarial activity against the drug resistant K1 strain of Plasmodium falciparum. In total, 86 Thai medicinal plant samples representing 48 species from 35 genera in 16 families were screened and two species (Polyalthia viridis and Goniothalamus marcanii) were found to show notable antimalarial activity (IC50: 10.0 and 6.3 μg/mL). Marcanine A and 16-hydroxycleroda-3,13(14)Z-dien-15,16- olide were identified as the respective major active constituents in P. viridis and G. marcanii, respectively. Copyright © 2006 John Wiley & Sons, Ltd.