Publication: Hyponatraemia and hypokalaemia in adults with uncomplicated malaria in Thailand
Issued Date
2008-01-01
Resource Type
ISSN
00494755
Other identifier(s)
2-s2.0-52049085763
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Doctor. Vol.38, No.3 (2008), 155-157
Suggested Citation
Vipa Thanachartwet, Srivicha Krudsood, Noppadon Tangpukdee, Weerapong Phumratanaprapin, Udomsak Silachamroon, Wattana Leowattana, Polrat Wilairatana, Gary M. Brittenham, Sornchai Looareesuwan, Guy H. Neild Hyponatraemia and hypokalaemia in adults with uncomplicated malaria in Thailand. Tropical Doctor. Vol.38, No.3 (2008), 155-157. doi:10.1258/td.2007.070112 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19817
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Title
Hyponatraemia and hypokalaemia in adults with uncomplicated malaria in Thailand
Abstract
In a retrospective study of 1415 patients aged 15 and over, we determined the incidence of clinically important hyponatraemia and hypokalaemia in adults with uncomplicated malaria. On admission, serum concentrations of sodium (135–145 mmol/L) and potassium (3.5–5.0 mmol/L) were found outside these reference ranges in 81% of patients. Severe hypokalaemia (K+ <3.0 mmol/L) and severe hyponatraemia (Na+ <125 mmol/L occurred in 4.4% and 0.6% of the patients, respectively. For hypokalaemia (43%) and hyponatraemia (37%), hypovolaemia, blood urea to creatinine ratio and high serum glucose (>100 mg/dL) were all independent factors (P < 0.001). Other independent predictors for hypokalaemia were Plasmodium vivax infection, female gender; and for hyponatraemia, P. falciparum infection, male gender, concentrations of G-6-PD and serum bicarbonate. © 2008, SAGE Publications. All rights reserved.