Publication: Relative incidence of agranulocytosis and aplastic anemia
Issued Date
2006-01-01
Resource Type
ISSN
10968652
03618609
03618609
Other identifier(s)
2-s2.0-30444432233
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Hematology. Vol.81, No.1 (2006), 65-67
Suggested Citation
David W. Kaufman, Judith P. Kelly, Surapol Issaragrisil, Joan Ramon Laporte, Theresa Anderson, Micha Levy, Samuel Shapiro, Neal S. Young Relative incidence of agranulocytosis and aplastic anemia. American Journal of Hematology. Vol.81, No.1 (2006), 65-67. doi:10.1002/ajh.20489 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23878
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Title
Relative incidence of agranulocytosis and aplastic anemia
Abstract
Agranulocytosis and aplastic anemia are both rare, life-threatening blood dyscrasias. Agranulocytosis is mainly caused by medicines, whereas the etiology of aplastic anemia is largely unexplained. In two epidemiologic studies using the same methods, we observed a striking inverse relationship between the incidence of the two diseases in different regions, including five countries in Europe, and Israel and Thailand. The annual incidence of agranulocytosis ranged from 1.1 to 4.9 cases per million, and that of aplastic anemia, from 0.7 to 4.1 per million; the inverse correlation was consistent among the regions (R 2 = 0.74). There is no clear explanation for this previously unreported pattern, but it seems unlikely to be due to methodology. © 2005 Wiley-Liss, Inc.