Publication: Pneumococci: Drug susceptibilities and preliminary epidemiological studies by penicillin binding protein genotyping
Issued Date
2005-05-01
Resource Type
ISSN
01251562
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2-s2.0-24944438301
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.3 (2005), 658-662
Suggested Citation
Somporn Srifeungfung, Sutiwan Thammawart, Amorn Leelarasamee, Kulkanya Chokephaibulkit, Surang Dejsirilert, Chanwit Tribuddharat Pneumococci: Drug susceptibilities and preliminary epidemiological studies by penicillin binding protein genotyping. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.3 (2005), 658-662. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16989
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Title
Pneumococci: Drug susceptibilities and preliminary epidemiological studies by penicillin binding protein genotyping
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Abstract
A collection of 307 pneumococcal isolates form 84 children and 223 adults admitted to Siriraj Hospital were separated into two groups, penicillin-susceptible (PSSP) and penicillin-nonsusceptible (PNSP). Each group was tested for susceptibilities to 12 drugs (cefuroxime, amoxicillin, chloramphenicol, tetracycline, cefotaxime, ceftriaxone, imipenem, meropenem, ciprofloxacin, ofloxacin, erythromycin and co-trimoxazole). PSSP were susceptible to cefuroxime (87.5%), amoxicillin (100%), chloramphenicol (84.7%), tetracycline (45.8%), cefotaxime (99%), ceftriaxone (99%), imipenem (99%), meropenem (100%), ciprofloxacin (76%), ofloxacin (99%), erythromycin (94.8%) and co-trimoxazole (61.5%). PNSP were resistant to most drugs, except for amoxicillin (99%), ofloxacin (99%) and ciprofloxacin (86.3%). Twenty-two pneumococcal isolates belonging to the three most common serotypes (6, 19, 23) were randomly selected for studies of the pbp2b gene with RFLP. There were 7 distinct pbp2b RFLP patterns. RFLP pattern 1 was the most predominant resistant pattern. The RFLP pattern 2 was found only in PSSP.