Publication: Lymphocytes in β-thalassemia/HbE: Subpopulations and mitogen responses
Issued Date
1996-03-28
Resource Type
ISSN
09024441
Other identifier(s)
2-s2.0-0029669974
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Haematology. Vol.56, No.3 (1996), 153-157
Suggested Citation
W. Wanachiwanawin, J. Phucharoen, K. Pattanapanyasat, S. Fucharoen, H. K. Webster Lymphocytes in β-thalassemia/HbE: Subpopulations and mitogen responses. European Journal of Haematology. Vol.56, No.3 (1996), 153-157. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17747
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Lymphocytes in β-thalassemia/HbE: Subpopulations and mitogen responses
Abstract
Lymphocyte subpopulations and proliferative responses to mitogens of 24 β-thalassemia/HbE patients were studied and compared with those of 23 healthy controls. Results of the study were analyzed in correlation with clinical aspects i.e. severity of disease (anemia), frequency of infections and iron status. T(CD3+) lymphocytes were found to increase in thalassemic patients compared to normal controls. The CD4- or CD8-positive lymphocytes and CD4/CD8 ratio were not statistically different from normals. Without mitogen, lymphocytes from thalassemic patients incorporated more [3H]Tdr than those from normal controls. Stimulation index (SI) of these cells after various mitogens were lower than in normal subjects. The observations were more obvious in patients with severe disease (severe anemia) and those who had frequent infections. These findings suggest that lymphocytes from thalassemic patients are activated in vivo. Whether these cells are less efficient in response to new or previously unexposed antigens remains to be proven.