Publication: Early origin and recent expansion of Plasmodium falciparum
Issued Date
2003-04-11
Resource Type
ISSN
00368075
Other identifier(s)
2-s2.0-0037432740
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Science. Vol.300, No.5617 (2003), 318-321
Suggested Citation
Deirdre A. Joy, Xiaorong Feng, Jianbing Mu, Tetsuya Furuya, Kesinee Chotivanich, Antoniana U. Krettli, May Ho, Alex Wang, Nicholas J. White, Edward Suh, Peter Beerli, Xin zhuan Su Early origin and recent expansion of Plasmodium falciparum. Science. Vol.300, No.5617 (2003), 318-321. doi:10.1126/science.1081449 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21048
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Early origin and recent expansion of Plasmodium falciparum
Abstract
The emergence of virulent Plasmodium falciparum in Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized. Here, we provide genetic evidence for a sudden increase in the African malaria parasite population about 10,000 years ago, followed by migration to other regions on the basis of variation in 100 worldwide mitochondrial DNA sequences. However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings.