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Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis

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dc.contributor.authorArada Rojana-Udomsarten_US
dc.contributor.authorChalermchai Mitrpanten_US
dc.contributor.authorIan Jamesen_US
dc.contributor.authorCampbell Witten_US
dc.contributor.authorMerrilee Needhamen_US
dc.contributor.authorTimothy Dayen_US
dc.contributor.authorLynette Kiersen_US
dc.contributor.authorAlastair Corbetten_US
dc.contributor.authorPatricia Martinezen_US
dc.contributor.authorSteve D. Wiltonen_US
dc.contributor.authorFrank L. Mastagliaen_US
dc.contributor.otherUniversity of Western Australiaen_US
dc.contributor.otherYala Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRoyal Perth Hospitalen_US
dc.contributor.otherRoyal North Shore Hospitalen_US
dc.contributor.otherUniversity of Sydney Faculty of Medicineen_US
dc.contributor.otherRoyal Melbourne Hospitalen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherConcord Repatriation General Hospitalen_US
dc.date.accessioned2018-10-19T05:06:03Z
dc.date.available2018-10-19T05:06:03Z
dc.date.issued2013-01-15en_US
dc.description.abstractWe compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM. © 2012 Elsevier B.V.en_US
dc.identifier.citationJournal of Neuroimmunology. Vol.254, No.1-2 (2013), 174-177en_US
dc.identifier.doi10.1016/j.jneuroim.2012.09.003en_US
dc.identifier.issn18728421en_US
dc.identifier.issn01655728en_US
dc.identifier.other2-s2.0-84871690509en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/31975
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871690509&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.subjectNeuroscienceen_US
dc.titleAnalysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84871690509&origin=inwarden_US

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