Publication: Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy
Issued Date
2010-12-01
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ISSN
1875855X
19057415
19057415
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2-s2.0-84871691748
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Biomedicine. Vol.4, No.6 (2010), 987-990
Suggested Citation
Narisa Futrakul, Punnee Butthep, Sirichan Chunhakan, Wansa Banyatsuppasin, Prasit Futrakul Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy. Asian Biomedicine. Vol.4, No.6 (2010), 987-990. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28586
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Title
Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy
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Abstract
Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier therapeutic strategy with vasodilators has improved renal function in normo-albuminuric type 2 DN. Objective: Study the mechanism of vascular homeostasis in twenty patients associated with normo-albuminuric type 2 DN. Results: Angiogenic factors were observed in normo-albuminuric type 2 DN, where vascular endothelial growth factor (VEGF), was 420 ± 341 vs. 428±291 pg/mL (normal), and vascular endothelial growth factor - receptor 1 (VEGF-R1) was 60±12 vs. 49±5 ng/mL (normal), which were not significantly different from the controls. Anti-angiogenic factors were observed in normo-albuminuric type 2 DN, where angiopoietin-2, was 2309±1125 vs. 1671±835 pg/mL (normal), and vascular endothelial growth factor - receptor 2 (VEGF-R2) was 5715±1400 vs.6126 ± 1060 ng/mL (normal), which were not significantly different from the controls. Conclusion: The mechanism of vascular homeostasis was adequately functional in normo-albuminuric type 2 DN. This mechanism may explain the positive response to vasodilators and improved renal function in early stage of type 2 DN following the vasodilator treatment.