Publication: Fine-needle aspiration cytology of parathyroid carcinoma mimic Hürthle cell thyroid neoplasm
Issued Date
2014-01-01
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ISSN
2090651X
20906501
20906501
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2-s2.0-84978089141
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Mahidol University
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SCOPUS
Bibliographic Citation
Case Reports in Endocrinology. Vol.2014, (2014)
Suggested Citation
Chutintorn Sriphrapradang, Pattana Sornmayura, Niramol Chanplakorn, Objoon Trachoo, Pattarana Sae-Chew, Rangsima Aroonroch Fine-needle aspiration cytology of parathyroid carcinoma mimic Hürthle cell thyroid neoplasm. Case Reports in Endocrinology. Vol.2014, (2014). doi:10.1155/2014/680876 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34594
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Title
Fine-needle aspiration cytology of parathyroid carcinoma mimic Hürthle cell thyroid neoplasm
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Abstract
Copyright © 2014 Chutintorn Sriphrapradang et al. Background. Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions. Case Presentation. A 31-year-old man presented with a palpable neck mass on the right thyroid lobe. FNA cytology was reported as intrathyroidal lymphoid hyperplasia. After 5 years, repeated FNA was done on the enlarged nodule with result of Hürthle cell lesion. Prior to right lobectomy, laboratories revealed elevated serum calcium and parathyroid hormone (PTH). Careful history taking revealed chronic knee pain and ossifying fibroma at the maxilla. Ultrasonography showed a 2.8 cm mass inferior to right thyroid lobe. Pathology from en bloc resection was parathyroid carcinoma and immunohistochemical study revealed positivity for PTH. Genetic analysis found somatic mutation of CDC73 gene in exon1 (c.70delG) which caused premature stop codon in amino acid 26 (p.Glu24Lysfs∗2). The final diagnosis was hyperparathyroidism-jaw tumor syndrome. Conclusions. FNA cytology of parathyroid can mimic thyroid lesion. It is important to consider and correlate the entire information from clinical history, laboratory, imaging, and FNA.