Publication: Anti-HIV-1 constituents from Clausena excavata: Part II. Carbazoles and a pyranocoumarin
Issued Date
2005-08-01
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ISSN
0951418X
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2-s2.0-26444537378
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.19, No.8 (2005), 728-731
Suggested Citation
Boonsong Kongkathip, Ngampong Kongkathip, Arunrat Sunthitikawinsakul, Chanita Napaswat, Chalobon Yoosook Anti-HIV-1 constituents from Clausena excavata: Part II. Carbazoles and a pyranocoumarin. Phytotherapy Research. Vol.19, No.8 (2005), 728-731. doi:10.1002/ptr.1738 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16437
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Title
Anti-HIV-1 constituents from Clausena excavata: Part II. Carbazoles and a pyranocoumarin
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Abstract
Three carbazole derivatives, O-methylmukonal (1), 3-formyl-2,7- dimethoxycarbazole (2) and clauszoline J (3), and a pyranocoumarin, clausenidin (4), were isolated from the rhizomes and roots of Clausena excavata. Compound 1, isolated from this plant for the first time, has not been reported previously as having anti-HIV-1 activity. Compounds 1-4 displayed anti-HIV-1 activity in a syncytial assay with EC50 values of 12, 29.1, 34.2 and 5.3 μM, respectively, and thus exhibited potential therapeutic index (PTI) values of 56.7, 8.0, 1.6 and 7.0, respectively. All isolated compounds demonstrated a lack of cytotoxicity against the KB and BC-1 cancer cell lines. Copyright © 2005 John Wiley & Sons, Ltd.