Publication: "Hit-and-run": Transcription factors get caught in the act
Issued Date
2015-07-01
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15211878
02659247
02659247
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2-s2.0-84931958097
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Mahidol University
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SCOPUS
Bibliographic Citation
BioEssays. Vol.37, No.7 (2015), 748-754
Suggested Citation
Varodom Charoensawan, Claudia Martinho, Philip A. Wigge "Hit-and-run": Transcription factors get caught in the act. BioEssays. Vol.37, No.7 (2015), 748-754. doi:10.1002/bies.201400186 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35427
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"Hit-and-run": Transcription factors get caught in the act
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Abstract
© 2015 WILEY Periodicals, Inc.. A key challenge for understanding transcriptional regulation is being able to measure transcription factor (TF)-DNA binding events with sufficient spatial and temporal resolution; that is, when and where TFs occupy their cognate sites. A recent study by Para et al. has highlighted the dynamics underlying the activation of gene expression by a master regulator TF. This study provides concrete evidence for a long-standing hypothesis in biology, the "hit-and-run" mechanism, which was first proposed decades ago. That is, gene expression is dynamically controlled by a TF that transiently binds and activates a target gene, which might stay in a transcriptionally active state after the initial binding event has ended. Importantly, the experimental procedure introduced, TARGET, provides a useful way for identifying multiple target genes transiently bound by their regulators, which can be used in conjunction with other well-established methods to improve our understanding of transcriptional regulatory dynamics.