Publication: Treatment outcomes of advanced stage endometrial carcinoma (Stage III-IV) and related factors
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Issued Date
2020-01-01
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22288082
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2-s2.0-85088662003
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Mahidol University
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SCOPUS
Bibliographic Citation
Siriraj Medical Journal. Vol.72, No.2 (2020), 117-124
Suggested Citation
Jesada Wutitammasuk, Pattama Chaopotong Treatment outcomes of advanced stage endometrial carcinoma (Stage III-IV) and related factors. Siriraj Medical Journal. Vol.72, No.2 (2020), 117-124. doi:10.33192/Smj.2020.16 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/58227
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Title
Treatment outcomes of advanced stage endometrial carcinoma (Stage III-IV) and related factors
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Abstract
© 2019 Faculty of Medicine Siriraj Hospital, Mahidol University. Objective: The aim of this study was to determine treatment response, the recurrence rate, 3-year overall survival, 3-year recurrence-free survival, and associated prognostic factors for survival among advanced-stage endometrial carcinoma patients at Siriraj Hospital. Methods: This study was conducted at the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand. A total of 415 patients that were diagnosed with advanced-stage endometrial carcinoma during January 1998 to December 2014 were enrolled. Data retrieved from medical records included baseline characteristics, surgico-pathological reports, treatment protocol, follow-up data, treatment response, and recurrence status. Three-year survival and recurrence-free survival were estimated by Kaplan-Meier method. Various factors were analyzed for significant association with survival. Results: Four hundred of 415 cases were included in the final analysis. There were 282 (70.5%) and 118 (29.5%) patients that were diagnosed with stage III and IV disease, respectively. Two hundred and eighty-two patients had complete response after primary treatment, and 94 (33.3%) patients had disease recurrence. The median follow-up and survival times were 24.5 and 42.5 months, respectively. The 3-year survival rate was 50%, and the median recurrence-free interval was 12.25 months. Multivariate analysis revealed high-grade tumor histology, lymph node metastasis, Eastern Cooperative Oncology Group (ECOG) performance status, and menopausal status to be significant prognostic factors for overall survival. Conclusion: Median survival among patients with advanced-stage endometrial carcinoma after primary treatment was 3 years. The significant prognostic factors were high grade tumor histology, lymph node metastasis, ECOG performance status, and menopausal status.