Publication:
Predicting the relative impacts of maternal and neonatal respiratory syncytial virus (RSV) vaccine target product profiles: A consensus modelling approach

dc.contributor.authorWirichada Pan-Ngumen_US
dc.contributor.authorTimothy Kinyanjuien_US
dc.contributor.authorMoses Kitien_US
dc.contributor.authorSylvia Tayloren_US
dc.contributor.authorJean François Toussainten_US
dc.contributor.authorSompob Saralambaen_US
dc.contributor.authorThierry Van Effelterreen_US
dc.contributor.authorD. James Nokesen_US
dc.contributor.authorLisa J. Whiteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Manchesteren_US
dc.contributor.otherWellcome Trust Research Laboratories Nairobien_US
dc.contributor.otherGSK Vaccinesen_US
dc.contributor.otherThe University of Warwicken_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherJanssen Research and Developmenten_US
dc.date.accessioned2018-12-21T06:56:38Z
dc.date.accessioned2019-03-14T08:03:03Z
dc.date.available2018-12-21T06:56:38Z
dc.date.available2019-03-14T08:03:03Z
dc.date.issued2017-01-05en_US
dc.description.abstract© 2016 The Authors Background Respiratory syncytial virus (RSV) is the major viral cause of infant and childhood lower respiratory tract disease worldwide. Defining the optimal target product profile (TPP) is complicated due to a wide range of possible vaccine properties, modalities and an incomplete understanding of the mechanism of natural immunity. We report consensus population level impact projections based on two mathematical models applied to a low income setting. Method Two structurally distinct age-specific deterministic compartmental models reflecting uncertainty associated with the natural history of infection and the mechanism by which immunity is acquired and lost were constructed. A wide range of vaccine TPPs were explored including dosing regime and uptake, and effects in the vaccinated individual on infectiousness, susceptibility, duration of protection, disease severity and interaction with maternal antibodies and natural induced immunity. These were combined with a range of vaccine implementation strategies, targeting the highest priority age group and calibrated using hospitalization data from Kilifi County Hospital, Kenya. Findings Both models were able to reproduce the data. The impact predicted by the two models was qualitatively similar across the range of TPPs, although one model consistently predicted higher impact than the other. For a proposed realistic range of scenarios of TPP combinations, the models predicted up to 70% reduction in hospitalizations in children under five years old. Vaccine designs which reduced the duration and infectiousness of infection were predicted to have higher impacts. The models were sensitive to the coverage and rate of loss of vaccine protection but not to the interaction between vaccine and maternal/naturally acquired immunity. Conclusion The results suggest that vaccine properties leading to reduced virus circulation by lessening the duration and infectiousness of infection upon challenge are of major importance in population RSV disease control. These features should be a focus for vaccine development.en_US
dc.identifier.citationVaccine. Vol.35, No.2 (2017), 403-409en_US
dc.identifier.doi10.1016/j.vaccine.2016.10.073en_US
dc.identifier.issn18732518en_US
dc.identifier.issn0264410Xen_US
dc.identifier.other2-s2.0-85006997930en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/42020
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006997930&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titlePredicting the relative impacts of maternal and neonatal respiratory syncytial virus (RSV) vaccine target product profiles: A consensus modelling approachen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006997930&origin=inwarden_US

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