Publication: Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34
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2014-02-01
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18811469
00218820
00218820
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2-s2.0-84896877860
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Mahidol University
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SCOPUS
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Journal of Antibiotics. Vol.67, No.2 (2014), 167-170
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Ratklao Siriwach, Hiroshi Kinoshita, Shigeru Kitani, Yasuhiro Igarashi, Kanokthip Pansuksan, Watanalai Panbangred, Takuya Nihira Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34. Journal of Antibiotics. Vol.67, No.2 (2014), 167-170. doi:10.1038/ja.2013.103 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34907
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Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34
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As a result of the continued screening for new metabolites produced by endophytic fungi from Thai medicinal plants, two new triene fatty acid amides, bipolamides A (1) and B (2), were discovered from the endophytic fungus Bipolaris sp. MU34. The structures of all of the isolated compounds were elucidated on the basis of the spectroscopic data of NMR and MS. An antimicrobial assay revealed that bipolamide B (2) had moderate antifungal activity against Cladosporium cladosporioides FERMS-9, Cladosporium cucumerinum NBRC 6370, Saccharomyces cerevisiae ATCC 9804, Aspergillus niger ATCC 6275 and Rhisopus oryzae ATCC 10404, with Minimum inhibitory concentration (MIC) values of 16, 32, 32, 64 and 64 μg ml -1, respectively. © 2014 Japan Antibiotics Research Association.