Publication: Profiling the host response to malaria vaccination and malaria challenge
1
Issued Date
2015-01-01
Resource Type
ISSN
18732518
0264410X
0264410X
Other identifier(s)
2-s2.0-84941810075
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vaccine. Vol.33, No.40 (2015), 5316-5320
Suggested Citation
Susanna Dunachie, Adrian V.S. Hill, Helen A. Fletcher Profiling the host response to malaria vaccination and malaria challenge. Vaccine. Vol.33, No.40 (2015), 5316-5320. doi:10.1016/j.vaccine.2015.07.107 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35636
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Title
Profiling the host response to malaria vaccination and malaria challenge
Abstract
© 2015 The Authors. A vaccine for malaria is urgently required. The RTS,S vaccine represents major progress, but is only partially effective. Development of the next generation of highly effective vaccines requires elucidation of the protective immune response. Immunity to malaria is known to be complex, and pattern-based approaches such as global gene expression profiling are ideal for understanding response to vaccination and protection against disease. The availability of experimental sporozoite challenge in humans to test candidate malaria vaccines offers a precious opportunity unavailable for other current targets of vaccine research such as HIV, tuberculosis and Ebola. However, a limited number of transcriptional profiling studies in the context of malaria vaccine research have been published to date. This review outlines the background, existing studies, limits and opportunities for gene expression studies to accelerate malaria vaccine research.