Publication:
Strict tropism for CD71<sup>+</sup>/CD234<sup>+</sup> human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

Issued Date

2017-09-14

Resource Type

Article

ISSN

15280020
00064971

DOI

10.1182/blood-2017-02-764787

Other identifier(s)

2-s2.0-85029468428

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Blood. Vol.130, No.11 (2017), 1357-1363

Suggested Citation

Varakorn Kosaisavee, Rossarin Suwanarusk, Adeline C.Y. Chua, Dennis E. Kyle, Benoit Malleret, Rou Zhang, Mallika Imwong, Rawiwan Imerbsin, Ratawan Ubalee, Hugo Sámano-Sánchez, Bryan K.S. Yeung, Jessica J.Y. Ong, Eric Lombardini, François Nosten, Kevin S.W. Tan, Pablo Bifani, Georges Snounou, Laurent Rénia, Bruce Russell Strict tropism for CD71<sup>+</sup>/CD234<sup>+</sup> human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. Blood. Vol.130, No.11 (2017), 1357-1363. doi:10.1182/blood-2017-02-764787 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41814

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Title

Strict tropism for CD71<sup>+</sup>/CD234<sup>+</sup> human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

Author(s)

Varakorn Kosaisavee
 Rossarin Suwanarusk
 Adeline C.Y. Chua
 Dennis E. Kyle
 Benoit Malleret
 Rou Zhang
 Mallika Imwong
 Rawiwan Imerbsin
 Ratawan Ubalee
 Hugo Sámano-Sánchez
 Bryan K.S. Yeung
 Jessica J.Y. Ong
 Eric Lombardini
 François Nosten
 Kevin S.W. Tan
 Pablo Bifani
 Georges Snounou
 Laurent Rénia
 Bruce Russell

Other Contributor(s)

Mahidol University
 Yong Loo Lin School of Medicine
 A-Star, Singapore Immunology Network
 University of Otago
 University of South Florida Health
 Armed Forces Research Institute of Medical Sciences, Thailand
 Novartis Institute of Tropical Diseases
 Nuffield Department of Clinical Medicine
 Sorbonne Universite
 CNRS Centre National de la Recherche Scientifique

Abstract

© 2017, American Society of Hematology. All rights reserved. Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date, only a single case of naturally acquired P cynomolgi has been found in humans. In this study, we show that whereas P cynomolgi merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234). This likely contributes to the paucity of detectable zoonotic cynomolgi malaria. We further describe postinvasion morphologic and rheologic alterations in P cynomolgi–infected human reticulocytes that are strikingly similar to those observed for P vivax. These observations stress the value of P cynomolgi as a model in the development of blood stage vaccines against vivax malaria.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/41814

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Scopus 2016-2017