Publication: Article ipmi: Machine learning-aided identification of parametrial invasion in women with early-stage cervical cancer
Issued Date
2021-08-01
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20754418
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2-s2.0-85112751764
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Mahidol University
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SCOPUS
Bibliographic Citation
Diagnostics. Vol.11, No.8 (2021)
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Phasit Charoenkwan, Watshara Shoombuatong, Chalaithorn Nantasupha, Tanarat Muangmool, Prapaporn Suprasert, Kittipat Charoenkwan Article ipmi: Machine learning-aided identification of parametrial invasion in women with early-stage cervical cancer. Diagnostics. Vol.11, No.8 (2021). doi:10.3390/diagnostics11081454 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76080
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Article ipmi: Machine learning-aided identification of parametrial invasion in women with early-stage cervical cancer
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Abstract
Radical hysterectomy is a recommended treatment for early-stage cervical cancer. How-ever, the procedure is associated with significant morbidities resulting from the removal of the parametrium. Parametrial cancer invasion (PMI) is found in a minority of patients but the efficient system used to predict it is lacking. In this study, we develop a novel machine learning (ML)-based predictive model based on a random forest model (called iPMI) for the practical identification of PMI in women. Data of 1112 stage IA-IIA cervical cancer patients who underwent primary surgery were collected and considered as the training dataset, while data from an independent cohort of 116 consec-utive patients were used as the independent test dataset. Based on these datasets, iPMI-Econ was then developed by using basic clinicopathological data available prior to surgery, while iPMI-Power was also introduced by adding pelvic node metastasis and uterine corpus invasion to the iPMI-Econ. Both 10-fold cross-validations and independent test results showed that iPMI-Power outperformed other well-known ML classifiers (e.g., logistic regression, decision tree, k-nearest neighbor, multi-layer perceptron, naive Bayes, support vector machine, and extreme gradient boosting). Upon comparison, it was found that iPMI-Power was effective and had a superior performance to other well-known ML classifiers in predicting PMI. It is anticipated that the proposed iPMI may serve as a cost-effective and rapid approach to guide important clinical decision-making.