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Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity

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dc.contributor.authorJutamas Apisornopasen_US
dc.contributor.authorPatamawadee Silalaien_US
dc.contributor.authorTeerapich Kasemsuken_US
dc.contributor.authorAnan Athipornchaien_US
dc.contributor.authorUthaiwan Sirionen_US
dc.contributor.authorKanoknetr Suksenen_US
dc.contributor.authorPawinee Piyachaturawaten_US
dc.contributor.authorApichart Suksamrarnen_US
dc.contributor.authorRungnapha Saeengen_US
dc.contributor.otherRambhai Barni Rajabhat Universityen_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherBurapha Universityen_US
dc.date.accessioned2019-08-23T10:33:35Z
dc.date.available2019-08-23T10:33:35Z
dc.date.issued2018-05-15en_US
dc.description.abstract© 2018 Elsevier Ltd New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.en_US
dc.identifier.citationBioorganic and Medicinal Chemistry Letters. Vol.28, No.9 (2018), 1558-1561en_US
dc.identifier.doi10.1016/j.bmcl.2018.03.068en_US
dc.identifier.issn14643405en_US
dc.identifier.issn0960894Xen_US
dc.identifier.other2-s2.0-85044503580en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/45167
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044503580&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleSynthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activityen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044503580&origin=inwarden_US

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