Publication:
Chiral phosphoric acid-catalyzed enantioselective aza-Friedel-Crafts alkylation of indoles with γ-hydroxy-γ-lactams

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dc.contributor.authorThibaut Couranten_US
dc.contributor.authorSirirat Kumarnen_US
dc.contributor.authorLong Heen_US
dc.contributor.authorPascal Retailleauen_US
dc.contributor.authorGéraldine Massonen_US
dc.contributor.otherInstitut de Chimie des Substances Naturellesen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-19T04:45:51Z
dc.date.available2018-10-19T04:45:51Z
dc.date.issued2013-03-25en_US
dc.description.abstractAn enantioselective aza-Friedel-Crafts reaction of indoles with γ-hydroxy-γ-lactams using a chiral phosphoric acid catalyst is reported. The approach described herein provides an efficient access to 5-indolylpyrrolidinones in good to quantitative yields and excellent enantioselectivities (up to >99% ee). The results suggest that the reaction may proceed via N-acyliminium intermediates associated with the chiral phosphoric acid anion. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.identifier.citationAdvanced Synthesis and Catalysis. Vol.355, No.5 (2013), 836-840en_US
dc.identifier.doi10.1002/adsc.201201008en_US
dc.identifier.issn16154169en_US
dc.identifier.issn16154150en_US
dc.identifier.other2-s2.0-84875458564en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/31483
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875458564&origin=inwarden_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.titleChiral phosphoric acid-catalyzed enantioselective aza-Friedel-Crafts alkylation of indoles with γ-hydroxy-γ-lactamsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875458564&origin=inwarden_US

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