Publication:
The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress

Issued Date

1987-01-01

Resource Type

Article

ISSN

00359203

DOI

10.1016/0035-9203(87)90003-4

Other identifier(s)

2-s2.0-0023622465

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.81, No.5 (1987), 710-714

Suggested Citation

Sudaratana Rochanakij Krungkrai, Yongyuth Yuthavong The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.81, No.5 (1987), 710-714. doi:10.1016/0035-9203(87)90003-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15361

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Title

The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress

Author(s)

Sudaratana Rochanakij Krungkrai
 Yongyuth Yuthavong

Other Contributor(s)

Rajavithi Hospital
 Mahidol University

Abstract

The antimalarial activity of qinghaosu (artemisinine) against Plasmodium falciparum in culture was enhanced by increased oxygen tension. Artesunate, a qinghaosu derivative, showed synergistic effects with miconazole, and with doxorubicin, both of which have been suggested to exert their chemotherapeutic effect through increasing the oxidant stress. In contrast, catalase, dithiothreitol and α-tocopherol reduced the effectiveness of qinghaosu in vitro. These results suggest that the action of qinghaosu and artesunate might involve increase in oxidant stress on the infected red cells. © 1987.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/15361

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Scopus 1969-1990