Publication: Cardiometabolic risk in thai adults with type 2 diabetes mellitus: Obese versus non-obese
Issued Date
2015-06-01
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01252208
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2-s2.0-84933529369
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.98, No.6 (2015), 528-534
Suggested Citation
Supornpim Chearskul, Apiradee Sriwijitkamol, Suwattanee Kooptiwut, Smarn Ornreabroi, Malika Churintaraphan, Namoiy Samprasert Cardiometabolic risk in thai adults with type 2 diabetes mellitus: Obese versus non-obese. Journal of the Medical Association of Thailand. Vol.98, No.6 (2015), 528-534. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36412
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Title
Cardiometabolic risk in thai adults with type 2 diabetes mellitus: Obese versus non-obese
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Abstract
© 2015, Medical Association of Thailand. All rights reserved. Background: Adiposity is an inflammatory condition contributing to the morbidity and mortality of several disorders, including type 2 diabetes mellitus (T2DM) and cardiovascular disease. Objective: To compare cardiometabolic risk factors between obese and non-obese Thai patients with T2DM. Material and Method: The cross-sectional study was done in 20 obese (BMI ≥25 kg/m2) and 20 non-obese (BMI ≤23 kg/m2) T2DM. Researchers measured fasting plasma glucose and lipids, serum levels of insulin, leptin, adiponectin, and soluble tumor necrosis factor-alpha receptors type 1 and 2 (sTNF-R1 and sTNF-R2). Insulin sensitivity check index (QUICIKI) and insulin resistance index (HOMA-IR) were calculated. Results: Thai obese adults with T2DM had greater amounts of sTNF-R2 and HOMA-IR, higher ratios of leptin/adiponectin, and more incidences of hypertension and hypertriglyceridemia in comparison to non-obese counterparts. Additionally, HOMA-IR values in non-obese T2DM were greater than those reported among non-diabetic Thai adults. A reverse association between inflammatory markers (both sTNF-Rs) and HDLC was detected. Leptin/adiponectin ratios correlated directly with HOMA-IR, serum insulin, plasma triglycerides and BMI, whereas HOMA-IR did not relate to any studied plasma lipid. Conclusion: The present study demonstrated an increased cardiometabolic risk in obese T2DM adults than non-obese T2DM adults among the Thai population. The leptin/adiponectin ratio may be more relevant to predict the risk of cardiovascular events in T2DM patients than HOMA-IR.