Publication: Comparison of the acute pulmonary vasodilating effect of beraprost sodium and nitric oxide in congenital heart disease - Thailand multicenter study
Issued Date
2005-01-01
Resource Type
ISSN
13469843
Other identifier(s)
2-s2.0-12344324471
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Mahidol University
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SCOPUS
Bibliographic Citation
Circulation Journal. Vol.69, No.1 (2005), 61-64
Suggested Citation
Kritvikrom Durongpisitkul, Duangmanee Laoprasitiporn, Thanarat Layangool, Rekwan Sittiwankul, Mannat Panamonta, Pirapat Mokrapong Comparison of the acute pulmonary vasodilating effect of beraprost sodium and nitric oxide in congenital heart disease - Thailand multicenter study. Circulation Journal. Vol.69, No.1 (2005), 61-64. doi:10.1253/circj.69.61 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17138
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Title
Comparison of the acute pulmonary vasodilating effect of beraprost sodium and nitric oxide in congenital heart disease - Thailand multicenter study
Abstract
Background: Congenital heart disease patients who have pulmonary hypertension (PH) require an evaluation for pulmonary vascular reactivity before surgical repair. In the present study the acute pulmonary vasodilating effects of 100% oxygen (O2), beraprost sodium (BPS) and 40 ppm inhaled nitric oxide (iNO) during cardiac catheterization were compared. Methods and Results: There were 90 patients who underwent cardiac catheterization for evaluation of PH (mean age, 16.5±16 years). The baseline mean pulmonary artery (mPA) pressure was 69.6±14.8 mmHg and the pulmonary arteriolar resistance (Rpa) was 13.8±8.3 Wood unit m2. Change in pulmonary vascular reactivity was defined as a decrease in mPA or Rpa >20% from baseline. The response to 100%O2, iNO and BPS during cardiac catheterization was 84%, 72.7% and 64%, respectively. Pair comparisons among each hemodynamic parameter showed no difference between the acute vasodilating effect of BPS and iNO. In some patients BPS showed a stronger effect than iNO in lowering Rpa. Conclusions: BPS has a similar pulmonary vasodilating effect to iNO and can be used as an acute pulmonary vasodilating agent during cardiac catheterization with potential benefits over iNO.