Publication: Survival rate and risk factors of mortality among HIV/tuberculosis- coinfected patients with and without antiretroviral therapy
Issued Date
2006-09-01
Resource Type
ISSN
15254135
Other identifier(s)
2-s2.0-33748125153
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Acquired Immune Deficiency Syndromes. Vol.43, No.1 (2006), 42-46
Suggested Citation
Weerawat Manosuthi, Suthat Chottanapand, Supeda Thongyen, Achara Chaovavanich, Somnuek Sungkanuparph Survival rate and risk factors of mortality among HIV/tuberculosis- coinfected patients with and without antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes. Vol.43, No.1 (2006), 42-46. doi:10.1097/01.qai.0000230521.86964.86 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23306
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Title
Survival rate and risk factors of mortality among HIV/tuberculosis- coinfected patients with and without antiretroviral therapy
Abstract
BACKGROUND: The impact of antiretroviral therapy (ART) on survival among patients coinfected with HIV and tuberculosis (TB) has not been well established. METHODS: A retrospective cohort study was conducted among HIV-infected patients with TB between January 2000 and December 2004. Patients were categorized into ART+ group (received ART) and ART- group (did not receive ART) and were followed until April 2005. RESULTS: A total of 1003 patients were identified; 411 in ART+ group and 592 in ART- group. Median (interquartile range) CD4 count was 53 (20-129) cells/mm. Survival rates at 1, 2, and 3 years after TB diagnosis were 96.1%, 94.0%, and 87.7% for ART+ group and 44.4%, 19.2%, and 9.3% for ART- group (log-rank test, P < 0.001). Cox proportional hazard model showed that ART was associated with lower mortality rate; gastrointestinal TB and multidrug resistant TB were associated with higher mortality rate (P < 0.05). Among patients in ART+ group, the patients who delayed ART ≥6 months after TB diagnosis had a higher mortality rate than those who initiated ART <6 months after TB diagnosis (P 0.018, hazard ratio = 2.651, 95% confidence interval = 1.152-6.102). CONCLUSIONS: Antiretroviral therapy substantially reduces mortality rate among HIV/TB-coinfected patients. Initiation of ART within 6 months of TB diagnosis is associated with greater survival. Copyright © 2006 by Lippincott Williams & Wilkins.