Publication: Rhabdomyolysis associated with severe levodopa-induced dyskinesia in parkinson’s disease: A report of two cases and literature review
Issued Date
2021-01-01
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21608288
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2-s2.0-85116714892
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Mahidol University
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SCOPUS
Bibliographic Citation
Tremor and Other Hyperkinetic Movements. Vol.11, No.1 (2021)
Suggested Citation
Yuvadee Pitakpatapee, Jindapa Srikajon, Tanita Sangpeamsook, Prachaya Srivanitchapoom Rhabdomyolysis associated with severe levodopa-induced dyskinesia in parkinson’s disease: A report of two cases and literature review. Tremor and Other Hyperkinetic Movements. Vol.11, No.1 (2021). doi:10.5334/tohm.641 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78595
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Title
Rhabdomyolysis associated with severe levodopa-induced dyskinesia in parkinson’s disease: A report of two cases and literature review
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Abstract
Background: Rhabdomyolysis associated with levodopa-induced dyskinesia (Rhab-LID) is an extremely rare, life-threatening, but treatable condition in patients with Parkinson’s disease (PD). Case report: We reported two cases of Rhab-LID. The first case was a 64-year-old man presenting with severe generalized dyskinesia with elevated serum creatine kinase (CK) level. He was diagnosed with Rhab-LID owing to unpredictable gastric emptying time. The second case was a 61-year-old woman presenting with fever, myalgia, and disabling dyskinesia with elevated serum CK. She was diagnosed with dyskinesia-hyperpyrexia syndrome (DHS) due to increasing dosage of ropinirole and infection. Dopaminergic medications were stopped, and supportive care was initiated in both cases with excellent outcomes. Conclusion: Early recognition, stopping dopaminergic medications, treating precipitating causes, and proper supportive treatment can provide favorable outcomes.