Publication: Virilization associated with choriocarcinoma
Issued Date
1995-01-01
Resource Type
ISSN
17208386
03914097
03914097
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2-s2.0-0028849451
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Endocrinological Investigation. Vol.18, No.8 (1995), 653-655
Suggested Citation
Rajata Rajatanavin, S. Chuahirun, L. Chailurkit, S. Srisupundit, S. Tungtrakul Virilization associated with choriocarcinoma. Journal of Endocrinological Investigation. Vol.18, No.8 (1995), 653-655. doi:10.1007/BF03349784 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17255
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Title
Virilization associated with choriocarcinoma
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Abstract
We demonstrate here two autopsy-proven cases of virilization associated with choriocarcinoma. The first patient was a 27-year-old woman with a 7-year history of metastatic choriocarcinoma who presented with left hemiparesis and virilization. Serum testosterone concentration was 18 nmol/l, free testosterone 471 pmol/l, dehydroepiandrosterone sulphate (DHEA-sulphate) 1.7 μmol/l, sex hormone binding globulin 12.3 nmol/l, estradiol (E2) 1,843 pmol/l, and hCG 1.6 × 105IU/I. The second patient was a 21-year-old virilized woman with metastatic choriocarcinoma who presented in semicomatose state. Limited endocrine investigation revealed serum testosterone 27 nmol/l and hCG 2.7 × 105IU/I. Both patients died despite chemotherapy and radiation therapy. Autopsy findings revealed choriocarcinoma with brain and multiple organ metastasis in both. Pathology of the ovaries of both patients demonstrated hyperplasia of luteinized theca cells and lutein cells. We postulate that an association of virilization and choriocarcinoma resulted from long-standing stimulation of ovary by hCG causing theca cell hyperplasia with subsequent hypertestosteronemia and virilization. © 1995, Italian Society of Endocrinology (SIE). All rights reserved.