Publication: Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses
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Accepted Date
2011-06-18
Issued Date
2011-07-18
Copyright Date
2011
Resource Type
Language
eng
ISSN
1756-3305 (electronic)
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Mahidol University
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BioMed Central
Bibliographic Citation
Patramool S, Surasombatpattana P, Luplertlop N, Sévéno M, Choumet V, Thomas F, et al. Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses. Parasit Vectors. 2011 Jul 18;4:138.
Suggested Citation
Sirilaksana Patramool, Pornapat Surasombatpattana, Natthanej Luplertlop, Sévéno, Martial, Choumet, Valérie, Thomas, Frédéric, Missé, Dorothée Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses. Patramool S, Surasombatpattana P, Luplertlop N, Sévéno M, Choumet V, Thomas F, et al. Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses. Parasit Vectors. 2011 Jul 18;4:138.. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/687
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Title
Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses
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Abstract
BACKGROUND: Proteomic analysis was performed to identify proteins regulated
during infection by Dengue serotypes 1 and 3 in an Aedes albopictus cell line.
The potential of these viruses to cause severe disease at primary infection is of
interest although few studies have been performed with these two Dengue
serotypes.
RESULTS: The most relevant observation of our study is the significant
overexpression of proteins involved in the cellular stress response and the
glycolysis pathway after 48 hours of infection. Viral infection activates the
translation of some host genes, which may result in stress due to responses
involving unfolded proteins.
CONCLUSIONS: Therefore, the oxidation reduction and glycolytic mechanisms could
participate in the antiviral response against Dengue virus. The results of our
study should help to improve our knowledge of the virus-mosquito interaction at a
cellular level with the aim of designing efficient strategies for the control of
Dengue virus.