Publication: Rectal pH in well and unwell infants
2
Issued Date
2012-08-01
Resource Type
ISSN
14653664
01426338
01426338
Other identifier(s)
2-s2.0-84864915869
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Tropical Pediatrics. Vol.58, No.4 (2012), 311-313
Suggested Citation
Claudia Turner, Naw Aye Mya Thein, Paul Turner, François Nosten, Nicholas J. White Rectal pH in well and unwell infants. Journal of Tropical Pediatrics. Vol.58, No.4 (2012), 311-313. doi:10.1093/tropej/fmr088 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14712
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Title
Rectal pH in well and unwell infants
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Abstract
Prompt antibiotic treatment for infants with sepsis has the potential to save lives. A rectal formulation of an antibiotic could be used at a village level before referral to hospital. The development of such a preparation needs to take into account the rectal pH of infants that will affect drug partitioning and absorption. Rectal pH measurements were taken in 100 well and 45 unwell infants. We also measured rectal pH in 14 infants sequentially over the course of their illness. The mean rectal pH was 6.75 with no significant difference in well or unwell infants. The mean (95% CI) rectal pH of well neonates was significantly lower than that of older infants ( > 28 days): 6.47 (6.29-6.65) vs. 6.90 (6.68 to 7.12) p = 0.003. © The Author [2011]. Published by Oxford University Press. All rights reserved.