Publication: Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica
Issued Date
2002-01-01
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ISSN
14727781
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2-s2.0-0036027104
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Chemical Society. Perkin Transactions 1. Vol.22, (2002), 2473-2476
Suggested Citation
Maneekarn Chinworrungsee, Prasat Kittakoop, Masahiko Isaka, Ratchada Chanphen, Morakot Tanticharoen, Yodhathai Thebtaranonth Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica. Journal of the Chemical Society. Perkin Transactions 1. Vol.22, (2002), 2473-2476. doi:10.1039/b207887m Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20139
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Title
Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica
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Abstract
Structurally unique isocoumarin glucosides, named halorosellins A (1) and B (2), were isolated from the EtOAc extract of a broth of the marine fungus Halorosellinia oceanica. Other new minor metabolites including 4,8-dihydroxy-6-methoxy-4,5-dimethyl-3-methyleneisochroman-1-one (3), 3-acetyl-7-hydroxy-5-methoxy-3,4-dimethyl-3H-isobenzofuran-1-one (4) and an ophiobolane sesterterpene, 17-dehydroxyhalorosellinic acid (5), were also isolated. Structures of these compounds were elucidated by analyses of spectroscopic data. Compound 4 exhibited mild antimycobacterial activity (MIC value of 200 μg mL-1).