Publication: Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa Linn. (roselle) in vitro using rat low-density lipoprotein (LDL)
Issued Date
2005-03-01
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ISSN
09186158
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2-s2.0-21144448920
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Mahidol University
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SCOPUS
Bibliographic Citation
Biological and Pharmaceutical Bulletin. Vol.28, No.3 (2005), 481-484
Suggested Citation
Vilasinee Hirunpanich, Anocha Utaipat, Noppawan Phumala Morales, Nuntavan Bunyapraphatsara, Hitoshi Sato, Angkana Herunsalee, Chuthamanee Suthisisang Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa Linn. (roselle) in vitro using rat low-density lipoprotein (LDL). Biological and Pharmaceutical Bulletin. Vol.28, No.3 (2005), 481-484. doi:10.1248/bpb.28.481 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17173
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Title
Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa Linn. (roselle) in vitro using rat low-density lipoprotein (LDL)
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Abstract
The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN, (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu2+-mediated oxidation of LDL (p<0.05) in vitro. The inhibitory effect of the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 μm of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro. © 2005 Pharmaceutical Society of Japan.