Publication: 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
Issued Date
2013-10-03
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ISSN
11778881
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2-s2.0-84885060514
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Design, Development and Therapy. Vol.7, (2013), 1157-1178
Suggested Citation
Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications. Drug Design, Development and Therapy. Vol.7, (2013), 1157-1178. doi:10.2147/DDDT.S49763 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32729
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Title
8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
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Abstract
Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships. © 2013 Prachayasittikul et al.