Publication: Effect of postpartum HIV treatment discontinuation on long-term maternal outcome
Issued Date
2008-09-01
Resource Type
ISSN
15570886
15451097
15451097
Other identifier(s)
2-s2.0-59049083593
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the International Association of Physicians in AIDS Care. Vol.7, No.5 (2008), 245-251
Suggested Citation
Nur F. Önen, Diana Nurutdinova, Somnuek Sungkanuparph, Debra Gase, Kristin Mondy, E. Turner Overton Effect of postpartum HIV treatment discontinuation on long-term maternal outcome. Journal of the International Association of Physicians in AIDS Care. Vol.7, No.5 (2008), 245-251. doi:10.1177/1545109708325466 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19296
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effect of postpartum HIV treatment discontinuation on long-term maternal outcome
Abstract
Background. Long-term maternal outcomes after postpartum antiretroviral therapy (ART) discontinuation are unknown. Methods. Retrospective review of pregnancies in HIV-infected women on treatment between 1997 and 2005. Women were grouped by postpartum ART use and followed until new opportunistic infection (OI), death or last clinic visit. Results. Of 172 pregnancies, postpartum ART discontinuation occurred in 123 (71.5%) women and was associated with greater parity, no partner during pregnancy, and no indication for OI prophylaxis or preconception ART in multivariate analysis (P <.05). Median follow-up was 32.5 months after delivery. There were 12 OIs and 2 deaths; 10 OIs and both deaths occurred in women who had discontinued ART. Conclusion. Postpartum ART discontinuation is common, especially among those with less advanced HIV disease, but may leave women at increased risk of long term adverse outcomes. This study highlights the need for larger longitudinal studies to determine appropriate recommendations for postpartum ART administration. © 2008 Sage Publications.