Publication: Immunogenicity and Protection from a Single Dose of Internationally Available Killed Oral Cholera Vaccine: A Systematic Review and Metaanalysis
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Issued Date
2018-06-01
Resource Type
ISSN
15376591
10584838
10584838
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2-s2.0-85048005104
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Infectious Diseases. Vol.66, No.12 (2018), 1960-1971
Suggested Citation
Anna Lena Lopez, Jacqueline Deen, Andrew S. Azman, Francisco J. Luquero, Suman Kanungo, Shanta Dutta, Lorenz Von Seidlein, David A. Sack Immunogenicity and Protection from a Single Dose of Internationally Available Killed Oral Cholera Vaccine: A Systematic Review and Metaanalysis. Clinical Infectious Diseases. Vol.66, No.12 (2018), 1960-1971. doi:10.1093/cid/cix1039 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46643
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Title
Immunogenicity and Protection from a Single Dose of Internationally Available Killed Oral Cholera Vaccine: A Systematic Review and Metaanalysis
Abstract
© 2017 The Author(s). In addition to improved water supply and sanitation, the 2-dose killed oral cholera vaccine (OCV) is an important tool for the prevention and control of cholera. We aimed to document the immunogenicity and protection (efcacy and effectiveness) conferred by a single OCV dose against cholera. Te metaanalysis showed that an estimated 73% and 77% of individuals seroconverted to the Ogawa and Inaba serotypes, respectively, afer an OCV frst dose. Te estimates of single-dose vaccine protection from available studies are 87% at 2 months decreasing to 33% at 2 years. Current immunologic and clinical data suggest that protection conferred by a single dose of killed OCV may be sufcient to reduce short-term risk in outbreaks or other high-risk settings, which may be especially useful when vaccine supply is limited. However, until more data suggest otherwise, a second dose should be given as soon as circumstances allow to ensure robust protection.