Publication: Risk factors and pathogenic significance of bacteremic pneumonia in adult patients with community-acquired pneumococcal pneumonia
Issued Date
2013-01-01
Resource Type
ISSN
15322742
01634453
01634453
Other identifier(s)
2-s2.0-84870729932
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infection. Vol.66, No.1 (2013), 34-40
Suggested Citation
Cheol In Kang, Jae Hoon Song, So Hyun Kim, Doo Ryeon Chung, Kyong Ran Peck, Visanu Thamlikitkul, Hui Wang, Thomas Man Kit So, Po Ren Hsueh, Rohani Md Yasin, Celia C. Carlos, Pham Hung Van, Jennifer Perera Risk factors and pathogenic significance of bacteremic pneumonia in adult patients with community-acquired pneumococcal pneumonia. Journal of Infection. Vol.66, No.1 (2013), 34-40. doi:10.1016/j.jinf.2012.08.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32701
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Title
Risk factors and pathogenic significance of bacteremic pneumonia in adult patients with community-acquired pneumococcal pneumonia
Other Contributor(s)
SungKyunKwan University, School of Medicine
Asia Pacific Foundation for Infectious Diseases (APFID)
Mahidol University
Peking Union Medical College
Princess Margaret Hospital Hong Kong
National Taiwan University Hospital
Institute for Medical Research Kuala Lumpur
Gokila
University of Medicine and Pharmacy
University of Colombo
Peking University
SureCare Medical Centre
Asia Pacific Foundation for Infectious Diseases (APFID)
Mahidol University
Peking Union Medical College
Princess Margaret Hospital Hong Kong
National Taiwan University Hospital
Institute for Medical Research Kuala Lumpur
Gokila
University of Medicine and Pharmacy
University of Colombo
Peking University
SureCare Medical Centre
Abstract
Objective: This study was performed to identify risk factors for the development of bacteremic pneumonia and to evaluate the impact of bacteremia on the outcome of pneumococcal pneumonia. Methods: Using a database from a surveillance study of community-acquired pneumococcal pneumonia, we compared data of the bacteremic group with that of the non-bacteremic group. Results: Among 981 adult patients with pneumococcal pneumonia, 114 (11.6%) patients who had documented pneumococcal bacteremia were classified into the bacteremic group. In a multivariable analysis, use of immunosuppressant drugs, younger age (<65 years), and DM were independent risk factors associated with the development of bacteremic pneumonia among patients with pneumococcal pneumonia (all P < 0.05). The mortality rate was significantly higher in the bacteremic group than in the non-bacteremic group (28.6% vs. 8.5%; P < 0.001). The multivariable analysis revealed that concomitant bacteremia was one of the significant risk factors associated with mortality (OR, 2.57; 95% CI, 1.24-5.29), along with cerebrovascular disease and presentation with septic shock (all P < 0.05). Conclusions: Bacteremia was a common finding in pneumococcal pneumonia and was associated with a higher mortality rate. Several clinical variables may be useful for predicting bacteremic pneumonia among patients with pneumococcal pneumonia. © 2012.