Publication:
Mechanism-Based Development of New Antimalarials: Synthesis of Derivatives of Artemisinin Attached to Iron Chelators

Issued Date

1995-06-01

Resource Type

Article

ISSN

15204804
00222623

DOI

10.1021/jm00013a007

Other identifier(s)

2-s2.0-0029044399

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Medicinal Chemistry. Vol.38, No.13 (1995), 2311-2316

Suggested Citation

Sumalee Kamchonwongpaisan, Sumpan Paitayatat, Yodhathai Thebtaranonth, Prapin Wilairat, Yongyuth Yuthavong Mechanism-Based Development of New Antimalarials: Synthesis of Derivatives of Artemisinin Attached to Iron Chelators. Journal of Medicinal Chemistry. Vol.38, No.13 (1995), 2311-2316. doi:10.1021/jm00013a007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17239

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Title

Mechanism-Based Development of New Antimalarials: Synthesis of Derivatives of Artemisinin Attached to Iron Chelators

Author(s)

Sumalee Kamchonwongpaisan
 Sumpan Paitayatat
 Yodhathai Thebtaranonth
 Prapin Wilairat
 Yongyuth Yuthavong

Other Contributor(s)

Mahidol University

Abstract

Various derivatives of artemisinin covalently linked to iron chelators were synthesized, and their antimalarial activities were evaluated. Although results show no indication that the presence of an iron chelator in the vicinity of artemisinin potentiates its action, the linked compounds prepared still retain comparable activities to that of artemisinin. © 1995, American Chemical Society. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/123456789/17239

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Scopus 1991-2000