Publication: Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1
Issued Date
1999-07-05
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0033051591
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.180, No.1 (1999), 50-55
Suggested Citation
Uraiwan Kositanont, Chantapong Wasi, Nirun Wanprapar, Piyaporn Bowonkiratikachorn, Kulkunya Chokephaibulkit, Sanay Chearskul, Kanittha Chimabutra, Ruengpung Sutthent, Suporn Foongladda, Reiko Inagi, Takeshi Kurata, Koichi Yamanishi Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1. Journal of Infectious Diseases. Vol.180, No.1 (1999), 50-55. doi:10.1086/314826 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25440
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Title
Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1
Abstract
The role of human herpesvirus 6 (HHV-6) infection in 227 children born to human immunodeficiency virus (HIV)-seropositive mothers was investigated. Of 41 HIV-uninfected infants, 3 (7%) were positive for HHV-6 DNA in the first month of life, suggesting possible intrauterine infection. The cumulative infection rates of HHV-6 at 6 and 12 months of age were significantly lower in HIV-infected children (11% and 33%, respectively) than in uninfected children (28% and 78%, respectively; P < .001). There was an association between high CD4+cell numbers (>15%) before HHV-6 infection and high HHV-6 infection rate. Twenty-two infants with HIV classed as Centers for Disease Control and Prevention stages N1 or N2 were studied for an association of HHV-6 infection with progression of HIV disease. Ten of the infants had HHV- 6, and 12 did not. In 5 of the infants without HHV-6 (42%), HIV disease had not progressed by 1 year of age; however, HIV disease had progressed in all 10 children with HHV-6 infection. These results suggest an association of HHV-6 infection and progression of HIV disease in the study children with vertical HIV-1 infection (P < .05).