Publication: Indole and Derivatives Modulate Biofilm Formation and Antibiotic Tolerance of Klebsiella pneumoniae
Issued Date
2019-12-01
Resource Type
ISSN
09737715
00468991
00468991
Other identifier(s)
2-s2.0-85074444314
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Indian Journal of Microbiology. Vol.59, No.4 (2019), 460-467
Suggested Citation
Thanachaporn Yaikhan, Manatsanan Chuerboon, Natchapol Tippayatham, Nateekarn Atimuttikul, Taiyeebah Nuidate, Mingkwan Yingkajorn, Aung Win Tun, Hansuk Buncherd, Natta Tansila Indole and Derivatives Modulate Biofilm Formation and Antibiotic Tolerance of Klebsiella pneumoniae. Indian Journal of Microbiology. Vol.59, No.4 (2019), 460-467. doi:10.1007/s12088-019-00830-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50984
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Indole and Derivatives Modulate Biofilm Formation and Antibiotic Tolerance of Klebsiella pneumoniae
Abstract
© 2019, Association of Microbiologists of India. Intercellular communication is a crucial process for the multicellular community in both prokaryotes and eukaryotes. Indole has been recognized as a new member of the signal molecules which enables the regulated control of various bacterial phenotypes. To elucidate the inter-species relationship among enteric microorganisms via indole signaling, Klebsiella pneumoniae (KP) culture was treated with indole solution and examined for the pathogenicity by using various phenotypic tests. Both synthetic and naturally-produced indole preparations had no deteriorating effect on growth and autoaggregative capacity of KP. The results showed that biofilm formation of carbapenem-susceptible K. pneumoniae (KP-S) was clearly induced by indole exposure (≈ 2–10 folds), whereas no significant difference was observed in the resistant counterpart. In addition, the tolerance to β-lactam antibiotics of KP was altered upon exposure to indole and/or derivatives assessed by Kirby–Bauer disk diffusion test. Taken together, our finding indicates the functional role of indole in changing or modulating pathogenic behaviors of other bacteria.