Publication: The promise and challenge of systems biology in translational medicine
Issued Date
2013-03-01
Resource Type
ISSN
01435221
Other identifier(s)
2-s2.0-84872246824
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Science. Vol.124, No.6 (2013), 389-390
Suggested Citation
Visith Thongboonkerd The promise and challenge of systems biology in translational medicine. Clinical Science. Vol.124, No.6 (2013), 389-390. doi:10.1042/CS20120565 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32449
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Title
The promise and challenge of systems biology in translational medicine
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Abstract
Abnormalities in clinical parameters and routine laboratory tests are frequently detected at late stages of many diseases (too late to cure or to prevent life-threatening complications). Hence earlier diagnostic and prognostic markers are needed for decision making and improving therapeutic outcome. In the present issue of Clinical Science, Rudiger and co-workers report findings from a transcriptomic study, which revealed that changes in transcripts involved in amino-sugar metabolism, p53-dependent cell-cycle arrest, β-adrenergic signalling and intracellular calcium cycling in cardiac tissue of rats with early sepsis could discriminate survivors from non-survivors. These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical practice. © The Authors Journal compilation.