Publication:
Direct determination of s-carboxymethyl-l-cysteine in syrups by reversed-phase high-performance liquid chromatography

Issued Date

2001-04-03

Resource Type

Article

ISSN

07317085

DOI

10.1016/S0731-7085(00)00479-9

Other identifier(s)

2-s2.0-0035079612

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Pharmaceutical and Biomedical Analysis. Vol.25, No.1 (2001), 165-170

Suggested Citation

Leena Suntornsuk Direct determination of s-carboxymethyl-l-cysteine in syrups by reversed-phase high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. Vol.25, No.1 (2001), 165-170. doi:10.1016/S0731-7085(00)00479-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26513

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Title

Direct determination of s-carboxymethyl-l-cysteine in syrups by reversed-phase high-performance liquid chromatography

Author(s)

Leena Suntornsuk

Other Contributor(s)

Mahidol University

Abstract

A simple reversed-phase high-performance liquid chromatography method was developed for the determination of s-carboxymethyl-l-cysteine in syrup preparations. The experiments were performed without specific sample pre-treatment. The LC conditions used were acetonitrile-10 mM sodium dihydrogenphosphate buffer, pH 2.0 (1:99, v/v) on a C18Inersil column with a flow rate of 1.5 ml/min. Ultraviolet detection was carried out at 240 nm. The method showed excellent linearity (r2> 0.9998) over the concentration range tested (0.8-25.6 mg/ml) with good precision and accuracy (%R.S.D. 0.7%). Recoveries were good (> 99%) with a limit of detection and limit of quantitation of 0.1 and 0.8 mg/ml. Other compositions in the syrup vehicle did not interfere the analysis of s-carboxymethyl-l-cysteine. © 2001 Elsevier Science B.V.

Keyword(s)

Chemistry
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/26513

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Scopus 2001-2005