Publication: In Vivo Antimalarial Activity and Toxicity Study of Extracts of Tagetes erecta L. And Synedrella nodiflora (L.) Gaertn. And the Asteraceae Family
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2021-01-01
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17414288
1741427X
1741427X
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2-s2.0-85110159106
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Mahidol University
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SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine. Vol.2021, (2021)
Suggested Citation
Prapaporn Chaniad, Tachpon Techarang, Arisara Phuwajaroanpong, Prasit Na-Ek, Parnpen Viriyavejakul, Chuchard Punsawad In Vivo Antimalarial Activity and Toxicity Study of Extracts of Tagetes erecta L. And Synedrella nodiflora (L.) Gaertn. And the Asteraceae Family. Evidence-based Complementary and Alternative Medicine. Vol.2021, (2021). doi:10.1155/2021/1270902 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78686
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Title
In Vivo Antimalarial Activity and Toxicity Study of Extracts of Tagetes erecta L. And Synedrella nodiflora (L.) Gaertn. And the Asteraceae Family
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Abstract
Objective. To investigate the antimalarial effects and toxicity of the extracts of the flowers of Tagetes erecta L. and the leaves of Synedrella nodiflora (L.) Gaertn. in a mouse model. Methods. To determine the in vivo antimalarial activity of the extracts, mice were intraperitoneally injected with the Plasmodium berghei ANKA strain and then administered T. erecta or S. nodiflora extract daily for 4 days. Parasitemia was observed by light microscopy. For the detection of acute toxicity, the mice received a single dose of T. erecta or S. nodiflora extract and were observed for 14 days. Biochemical parameters of liver and kidney function and the histopathology of liver and kidney tissues of the acute toxicity group were then examined. Results. T. erecta and S. nodiflora crude extracts at a dose of 600 mg/kg body weight significantly suppressed parasitemia in malaria-infected mice by 65.65% and 62.65%, respectively. Mice treated with 400 mg/kg T. erecta and S. nodiflora crude extracts showed 50.82% and 57.67% suppression, and mice treated with 200 mg/kg displayed 26.33% and 38.57% suppression, respectively. Additionally, no symptoms of acute toxicity were observed in the T. erecta- and S. nodiflora-treated groups. Moreover, no significant alterations in the biochemical parameters of liver and kidney function and no histological changes in the liver or kidney tissues were observed. Conclusions. This study revealed that both T. erecta and S. nodiflora extracts have antimalarial properties in vivo with less toxic effects. Further studies are needed to elucidate the mechanisms of the active compounds from both plants.