Publication: Role of burkholderia pseudomallei biofilm formation and lipopolysaccharide in relapse of melioidosis
Issued Date
2014-11-01
Resource Type
ISSN
14690691
1198743X
1198743X
Other identifier(s)
2-s2.0-84917689788
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Microbiology and Infection. Vol.20, No.11 (2014), O854-O856
Suggested Citation
D. Limmathurotsakul, A. Paeyao, S. Wongratanacheewin, N. Saiprom, N. Takpho, J. Thaipadungpanit, N. Chantratita, V. Wuthiekanun, N. P.J. Day, S. J. Peacock Role of burkholderia pseudomallei biofilm formation and lipopolysaccharide in relapse of melioidosis. Clinical Microbiology and Infection. Vol.20, No.11 (2014), O854-O856. doi:10.1111/1469-0691.12614 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34174
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Title
Role of burkholderia pseudomallei biofilm formation and lipopolysaccharide in relapse of melioidosis
Abstract
© 2014 The Authors. We examined whether quantitative biofilm formation and/or lipopolysaccharide type of Burkholderia pseudomallei was associated with relapsing melioidosis. We devised a 1: 4 nested case-control study in which both cases and controls were drawn from a cohort of patients with primary melioidosis. Paired isolates from 80 patients with relapse and single isolates from 184 patients without relapse were tested. Relapse was associated with biofilm formation of the primary infecting isolate (conditional OR 2.03; 95% CI 1.27-3.25; p 0.003), but not with lipopolysaccharide type (p 0.74). This finding highlights the importance of biofilm formation in relapsing melioidosis.